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How Cannabis Interacts with Prescription Medications
How Cannabis Affects Medication Metabolism
Cannabis is metabolized by the liver’s cytochrome P450 enzyme system (CYP450), which also processes many prescription drugs. This means cannabis can either:
- Slow down drug metabolism, increasing drug levels in the body.
- Speed up drug metabolism, making the drug less effective.
Common Medication Interactions
| Drug Type | How Cannabis Interacts | Potential Risks |
|---|---|---|
| Blood Thinners (Warfarin, Aspirin) | Slows metabolism | Increased risk of bleeding |
| Antidepressants (SSRIs, SNRIs) | Alters serotonin levels | Increased side effects, anxiety |
| Opioids (Morphine, Oxycodone) | Increases sedation | Heightened drowsiness, overdose risk |
| Diabetes Medications | Alters blood sugar | Hypoglycemia risk |
| Immunosuppressants | May reduce effectiveness | Potential transplant rejection |
How to Use Cannabis Safely with Medications
- ✅ Consult a doctor before mixing cannabis with prescription drugs.
- ✅ Start with low doses to monitor effects.
- ✅ Use CBD-dominant strains to reduce psychoactive risks.
- ✅ Avoid smoking if taking heart or lung-related medications.
Key Takeaways
- Cannabis can interact with many medications, altering their effects.
- THC and CBD are metabolized by the liver, affecting drug processing.
- Medical guidance is essential for those on prescription drugs.
Always discuss cannabis use with your doctor to prevent adverse interactions.